Copied!

Pathway Search


Limonene and pinene degradation

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
ATP + perillic_acid + CoA <=> Perillyl-CoA + AMP + diphosphate 6.2.1
6.2.1.M31
–
–
(1R,2R,4S)-limonene-1,2-diol + NAD+ <=> (1R,4S)-1-hydroxy-2-oxolimonene + NADH + H+ 1.1.1.297 limonene-1,2-diol dehydrogenase
–
2-Hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA + acceptor <=> 4-Isopropenyl-2-oxy-cyclohexanecarboxyl-CoA + reduced_acceptor 1.1
–
(3S,6S)-6-Isopropenyl-3-methyl-2-oxo-oxepanone + H2O <=> (5S)-6-Hydroxy-5-isopropenyl-2-methylhexanoate + H+ 3.1.1.83 monoterpene epsilon-lactone hydrolase
–
(1R,2R,4R)-dihydrocarveol + NAD+ <=> (4R)-dihydrocarvone + NADH + H+ 1.1.1.296 dihydrocarveol dehydrogenase
–
6,6-Dimethylbicyclo[3.1.1]hept-2-ene-2-methanol + O2 + acceptor <=> myrtenal + 2 H2O + reduced_acceptor 1.1
–
(1S,2S,4R)-iso-dihydrocarveol + NAD+ <=> (1R,4S)-isodihydrocarvone + NADH + H+ 1.1.1.296 dihydrocarveol dehydrogenase
–
(3R)-6-Hydroxy-3-isopropenyl-heptanoate <=> (3R)-3-isopropenyl-6-oxoheptanoate not assigned
 –
(-)-limonene + NADPH + H+ + O2 <=> (4S)-limonene-1,2-epoxide + NADP+ + H2O 1.14.13.107 limonene 1,2-monooxygenase
–
(4S)-7-Hydroxy-4-isopropenyl-7-methyl-2-oxo-oxepanone <=> H+ + (3S)-3-isopropenyl-6-oxoheptanoate 1.14.13.105 monocyclic monoterpene ketone monooxygenase
–
3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA + NAD+ <=> 2,6-Dimethyl-5-methylene-3-oxo-heptanoyl-CoA + NADH + H+ 1.1
–
cis-2-Methyl-5-isopropylhexa-2,5-dienoic_acid + ATP + CoA <=> cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + diphosphate 6.2.1
–
(4R)-dihydrocarvone + NADPH + H+ + O2 <=> (4R)-4-isopropenyl-7-methyl-2-oxo-oxepanone + NADP+ + H2O 1.14.13.105 monocyclic monoterpene ketone monooxygenase
–
(3S,6R)-6-Isopropenyl-3-methyl-2-oxo-oxepanone + H2O <=> (5R)-6-Hydroxy-5-isopropenyl-2-methylhexanoate + H+ 3.1.1.83 monoterpene epsilon-lactone hydrolase
–
(1R,4S)-1-hydroxy-2-oxolimonene + NADPH + H+ + O2 <=> (4S)-7-Hydroxy-4-isopropenyl-7-methyl-2-oxo-oxepanone + NADP+ + H2O 1.14.13.105 monocyclic monoterpene ketone monooxygenase
–
trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA 4.2.1.17 enoyl-CoA hydratase
–
Perillyl-CoA + H2O <=> 2-Hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA 4.2.1
–
(4R)-7-Hydroxy-4-isopropenyl-7-methyl-2-oxo-oxepanone <=> H+ + (3R)-3-isopropenyl-6-oxoheptanoate 1.14.13.105 monocyclic monoterpene ketone monooxygenase
–
(4R)-dihydrocarvone + acceptor <=> (-)-Carvone + reduced_acceptor 1.3.99.25 carvone reductase
–
1,2-epoxymenth-8-ene + H2O <=> (1S,2S,4R)-limonene-1,2-diol 3.3.2.8 limonene-1,2-epoxide hydrolase
–
2,6-Dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoA <=> 3-isopropylbut-3-enoyl-CoA + propionyl-CoA 2.3.1
–
myrtenal + H2O + acceptor <=> Myrtenic_acid + reduced_acceptor 1.2
–
(-)-alpha-pinene + O2 + 2 H+ + 2 e- <=> pino-carveol + H2O 1.14
–
3-isopropylbut-3-enoyl-CoA + H2O <=> 3-Isopropyl-3-butenoic_acid + CoA 3.1.2
–
(1S,2R,4R)-neoisodihydrocarveol + NAD+ <=> (-)-dihydrocarvone + NADH + H+ 1.1.1.296 dihydrocarveol dehydrogenase
–
(-)-limonene + NADH + H+ + O2 <=> (4S)-limonene-1,2-epoxide + NAD+ + H2O 1.14.13.107 limonene 1,2-monooxygenase
–
(+)-limonene + NADH + H+ + O2 <=> (R)-1,2-epoxy-limonene + NAD+ + H2O 1.14.13.107 limonene 1,2-monooxygenase
–
(-)-alpha-pinene + NADH + H+ + O2 <=> alpha-Pinene_oxide + NAD+ + H2O 1.14.13
1.14.13.155 alpha-pinene monooxygenase
–
–
(1R,4S)-isodihydrocarvone + NADPH + H+ + O2 <=> 4-isopropenyl-7-methyloxepan-2-one + NADP+ + H2O 1.14.13.105 monocyclic monoterpene ketone monooxygenase
–
(+)-trans-carveol + NAD+ <=> (S)-carvone + NADH + H+ 1.1.1.275 (+)-trans-carveol dehydrogenase
–
(+)-limonene + reduced_flavodoxin + O2 <=> (+)-trans-carveol + flavin + H2O 1.14.14.53 (R)-limonene 6-monooxygenase
–
(1R,4S)-isodihydrocarvone + O2 + NADPH + H+ <=> (3S,6R)-6-Isopropenyl-3-methyl-2-oxo-oxepanone + H2O + NADP+ 1.14.13.105 monocyclic monoterpene ketone monooxygenase
–
(-)-alpha-pinene + reduced_acceptor + O2 <=> 6,6-Dimethylbicyclo[3.1.1]hept-2-ene-2-methanol + H2O + acceptor 1.14
–
4-isopropenyl-7-methyloxepan-2-one + H2O <=> 6-hydroxy-3-isopropenylheptanoate + H+ 3.1.1.83 monoterpene epsilon-lactone hydrolase
–
(4S)-limonene-1,2-epoxide + H2O <=> (1R,2R,4S)-limonene-1,2-diol 3.3.2.8 limonene-1,2-epoxide hydrolase
–
6-hydroxy-3-isopropenylheptanoate <=> (3S)-3-isopropenyl-6-oxoheptanoate not assigned
 –
(-)-trans-carveol + NADP+ <=> (-)-Carvone + NADPH + H+ 1.1.1.243 carveol dehydrogenase
1.3.1.102 2-alkenal reductase (NADP+)
–
–
(1R,4S)-isodihydrocarvone <=> (-)-dihydrocarvone not assigned
 –
perillyl_alcohol + NAD+ <=> perillaldehyde + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.144 perillyl-alcohol dehydrogenase
1.1.1.347 geraniol dehydrogenase (NAD+)
1.1.1.90 aryl-alcohol dehydrogenase
1.14.14.51 (S)-limonene 6-monooxygenase
–
–
–
–
–
4-Isopropenyl-2-oxy-cyclohexanecarboxyl-CoA + H2O <=> 3-Isopropenylpimelyl-CoA 3.7.1
–
(4R)-4-isopropenyl-7-methyl-2-oxo-oxepanone + H2O <=> (3R)-6-Hydroxy-3-isopropenyl-heptanoate 3.1.1.83 monoterpene epsilon-lactone hydrolase
–
cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA 4.2.1.17 enoyl-CoA hydratase
–
(1R,4S)-isodihydrocarvone + acceptor <=> (S)-carvone + reduced_acceptor 1.3.99.25 carvone reductase
–
(+)-limonene + NADPH + H+ + O2 <=> (R)-1,2-epoxy-limonene + NADP+ + H2O 1.14.13.107 limonene 1,2-monooxygenase
–
(1R,2S,4R)-neo-dihydrocarveol + NAD+ <=> (4R)-dihydrocarvone + NADH + H+ 1.1.1.296 dihydrocarveol dehydrogenase
–
(3S)-3-isopropenyl-6-oxoheptanoate <=> (3S)-3-Isopropenyl-6-oxoheptanoyl-CoA 6.2.1
–
(4R)-dihydrocarvone <=> (1R,4S)-isodihydrocarvone not assigned
 –
(1S,2S,4R)-iso-dihydrocarveol + NAD+ <=> (1R,4S)-isodihydrocarvone + NADH + H+ 1.1.1.296 dihydrocarveol dehydrogenase
–
(+)-dihydrocarveol + NAD+ <=> (-)-dihydrocarvone + NADH + H+ 1.1.1.198 (+)-borneol dehydrogenase
1.1.1.296 dihydrocarveol dehydrogenase
–
–
perillic_acid + CoA + ATP <=> Perillyl-CoA + H2O + ADP + phosphate 6.2.1
–
trans-2-Methyl-5-isopropylhexa-2,5-dienoic_acid + ATP + CoA <=> trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + diphosphate 6.2.1
–
alpha-Pinene_oxide <=> (Z)-2-Methyl-5-isopropylhexa-2,5-dienal 5.5.1.10 alpha-pinene-oxide decyclase
–
(-)-dihydrocarvone + O2 + NADPH + H+ <=> (3S,6S)-6-Isopropenyl-3-methyl-2-oxo-oxepanone + H2O + NADP+ 1.14.13.105 monocyclic monoterpene ketone monooxygenase
–
(1S,2S,4R)-limonene-1,2-diol + NAD+ <=> (1S,4R)-1-hydroxy-2-oxolimonene + NADH + H+ 1.1.1.297 limonene-1,2-diol dehydrogenase
–
(-)-limonene + reduced_flavodoxin + O2 <=> (S)-perillyl_alcohol + flavin + H2O 1.14.14.52 (S)-limonene 7-monooxygenase
–
trans-2-Methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O <=> trans-2-Methyl-5-isopropylhexa-2,5-dienoic_acid + NADH + H+ 1.2.1
–
(1R,2S,4R)-neo-dihydrocarveol + NAD+ <=> (1R,4S)-isodihydrocarvone + NADH + H+ 1.1.1.296 dihydrocarveol dehydrogenase
–
(1S,2R,4R)-neoisodihydrocarveol + NAD+ <=> (1R,4S)-isodihydrocarvone + NADH + H+ 1.1.1.296 dihydrocarveol dehydrogenase
–
(-)-cis-carveol <=> (-)-Carvone not assigned
 –
(3R)-3-isopropenyl-6-oxoheptanoate + CoA + ATP <=> (3R)-3-Isopropenyl-6-oxoheptanoyl-CoA + H2O + AMP + diphosphate 6.2.1
–
(-)-limonene + reduced_flavodoxin + O2 <=> (-)-trans-carveol + flavin + H2O 1.14.14.51 (S)-limonene 6-monooxygenase
–
perillaldehyde + NAD+ + H2O <=> perillic_acid + NADH + H+ 1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
–
–
(2S,4S)-carveol <=> (S)-carvone not assigned
 –
(3R)-3-isopropenyl-6-oxoheptanoate + CoA + ATP <=> (3R)-3-Isopropenyl-6-oxoheptanoyl-CoA + ADP + phosphate 6.2.1
–
(Z)-2-Methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O <=> cis-2-Methyl-5-isopropylhexa-2,5-dienoic_acid + NADH + H+ 1.2.1
–
(1S,4R)-1-hydroxy-2-oxolimonene + NADPH + H+ + O2 <=> (4R)-7-Hydroxy-4-isopropenyl-7-methyl-2-oxo-oxepanone + NADP+ + H2O 1.14.13.105 monocyclic monoterpene ketone monooxygenase
–
pino-carveol <=> (-)-pinocarvone + H+ 1.1
–

Visualization of the pathway